18939

,

edited by Keith R. Fox

2nd ed

Humana Press, Springer Science+Business Media

xi, 318 p.:ill. (some col.)

Springer protocols Methods in molecular biology,1064-3745 ;613

Index

1. Quantitative analysis of small molecule-nucleic acid interactions with a biosensor surface and surface plasmon resonance detection / Yang Liu and W. David Wilson -- 2. Thermal melting studies of ligand DNA interactions / Aurore Guaedin, Laurent Lacroix, and Jean-Louis Mergny -- 3. Circular and linear dichroism of drug-DNA systems / Alison Rodger -- 4. Drug binding to DNA-RNA hybrid structures / Richard T. Wheelhouse and Jonathan B. Chaires -- 5. Quantification of binding data using capillary electrophoresis / Fitsumbirhan Araya, Graham G. Skellern, and Roger D. Waigh -- 6. Determination of equilibrium association constants of ligand-DNA complexes by electrospray mass spectrometry / Valaerie Gabelica -- 7. Detection of adriamycin-DNA adducts by accelerator mass spectrometry / Kate Coldwell ... [et al.] -- 8. Molecular modelling methods to quantitate drug-DNA interactions / Hao Wang and Charles A. Laughton -- 9. Application of anomalous diffraction methods to the study of DNA and DNA-complexes / Derrick Watkins ... [et al.] -- 10. DNase I footprinting / Antonia S. Cardew and Keith R. Fox -- 11. Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA / Vidya Subramanian ... [et al.] -- 12. REPSA: combinatorial approach for identifying preferred drug-DNA binding sequences / Michael W. Van Dyke -- 13. In vitro transcription assay for resolution of drug-DNA interactions at defined DNA sequences / Benny J. Evison, Don. R. Phillips, and Suzanne M. Cutts -- 14. In virtro footprinting of promoter regions within supercoiled plasmid DNA / Daekyu Sun -- 15. Topoisomerase I-mediated DNA relaxation as a tool to study intercalation of small molecules and supercoiled DNA / Paul Peixoto ... [et al.] -- 16. A high-throughput assay for DNA topoisomerases and other enzymes based on DNA triplex formation / Matthew R. Burrell, Nicolas P. Burton and Anthony Maxwell -- 17. Measurement of DNA interstrand crosslinking in individual cells using the single cell gel electrophoresis (Comet) assay / Victoria J. Spanswick, Janet M. Hartley, and John A. Hartley -- 18. Measurement of DNA interstrand crosslinking in naked DNA using Gel-based methods / Konstantinous Kiakos, Janet M. Hartley, and John A. Hartley -- 19. An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells / Mekala Gunaratnam and Stephen Neidle.

AU Fox, Keith R ed , ed , ed

QP

624.75

.D77,D78

jannati

1389/04/17

9781603274173 (hardcover : acid-free paper) ,

Includes bibliographical references

2010