15150

,

edited [by] Peter Paul De Deyn and Debby Van Dam

Humana Press

xv, 732 p. , ill.

Springer protocols,Neuromethods,0893-2336 ;48

General introduction to animal models of human conditions / Peter Paul De Deyn and Debby Van Dam -- Animal models of dementia : ethical considerations / I. Anna S. Olsson and Peter Sand²e -- The role of rodent models in the drug discovery pipeline for dementia / Debby Van Dam and Peter Paul De Deyn -- Species, strain, and gender issues in the development and validation of animal models of dementia / Annemie Van Dijck, Debby Van Dam, and Peter Paul De Deyn -- Transgenic and gene targeted models of dementia / Ronald A. Conlon -- Transgenic animals and intellectual property concerns / Susan L. Stoddard and James A. Rogers III -- Pathological validation of animal models of dementia / Daniel Pirici, Christine Van Broeckhoven, and Samir Kumar-Singh -- Behavioral validation in animal models of dementia / Debby Van Dam, Annemie Van Dijck, and Peter Paul De Deyn -- Pharmacological validation in animal models of dementia / Hugo Geerts -- Validation of animal models of dementia : neurochemical aspects / Giancarlo Pepeu and Maria Cristina Rosi -- Validation of dementia models employing neuroimaging techniques / Greet Vanhoutte, Adriaan Campo, and Annemie Van der Linden -- Drosophila melanogaster as a model organism for dementia / Maria E. Giannakou and Damian C. Crowther -- Caenorhabditis elegans as a model organism for dementia / Tjakko J. Van Ham and Ellen A.A. Nollen -- Zebrafish (Danio rerio) as a model organism for dementia / Rob Willemsen ... [et al.] -- Spontaneous vertebrate models of Alzheimer dementia : selectively bred strains (SAM strains) / Renoa A. Sowell and D. Allan Butterfield -- Lesion-induced vertebrate models of Alzheimer dementia / Adolfo Toledano and Maria Isabel aAlvarez -- A[Beta] infusion and related models of Alzheimer dementia / Patricia A. Lawlor and Deborah Young -- APP-based transgenic models : the PDAPP model / Jacob M. Basak and David M. Holtzman -- APP-based transgenic models : the Tg2576 model / Robert M.J. Deacon -- APP-based transgenic models : the APP23 model / Debby Van Dam and Peter Paul De Deyn -- Presenilin-based transgenic models of Alzheimerʹs dementia / Yuji Yoshiike and Akihiko Takashima -- APOE-based models of "pre-dementia" / Patrick M. Sullivan -- TAU models / Nicolas Sergeant and Luc Buaee -- The 3xTg-AD mouse model : reproducing and modulating plaque and tangle pathology / Michael Sy, Masashi Kitazawa, and Frank LaFerla -- Cognitive dysfunction in genetic mouse models of parkinsonism / Sheila M. Fleming, J. David Jentsch, and Marie-Francoise Chesselet -- Mouse models of metachromatic leukodystrophy and adrenoleukodystrophy / Patrick Aubourg, Caroline Sevin, and Nathatie Cartier -- Animal models of amyotrophic lateral sclerosis / Ludo Van Den Bosch -- Animal models of frontotemporal dementia / Hana N. Dawson and Daniel T. Laskowitz -- CADASIL : molecular mechanisms and animal models / Karl J. Fryxell -- Spontaneously hypertensive rat (SHR) : an animal model of vascular brain disorder / Francesco Amenta and Daniele Tomassoni -- Animal models of normal pressure hydrocephalus / Petra M. Klinge -- Animal models of traumatically-induced dementia / Jennifer E. Slemmer, Mohammad Z. Hossain, and John T. Weber -- Animal models of alcohol-induced dementia / Angela Maria Ribeiro and Silvia R. Castanheira Pereira -- Animal models of metallic dementia / Luigi F. Rodella.

AU Deyn, P. P. de(Peter P.) , AU Dam, Debby van.

220

WM

9781607618973 (alk. paper) ,

Includes bibliographical references and index.

c2011